diff --git a/vllm/v1/worker/gpu/block_table.py b/vllm/v1/worker/gpu/block_table.py
index e79a7afbd81..d2a2a6aedbf 100644
--- a/vllm/v1/worker/gpu/block_table.py
+++ b/vllm/v1/worker/gpu/block_table.py
@@ -47,18 +47,7 @@ class BlockTables:
                 device=device,
             )
             self.block_tables.append(block_table)
-        self.block_table_ptrs = self._make_ptr_tensor(
-            [b.gpu for b in self.block_tables]
-        )
-        self.block_table_strides = torch.tensor(
-            [b.gpu.stride(0) for b in self.block_tables],
-            dtype=torch.int64,
-            device=self.device,
-        )
 
-        self.block_sizes_tensor = torch.tensor(
-            self.block_sizes, dtype=torch.int32, device=self.device
-        )
         self.num_blocks = UvaBackedTensor(
             (self.num_kv_cache_groups, self.max_num_reqs),
             dtype=torch.int32,
@@ -69,7 +58,6 @@ class BlockTables:
         self.input_block_tables: list[torch.Tensor] = [
             torch.zeros_like(b.gpu) for b in self.block_tables
         ]
-        self.input_block_table_ptrs = self._make_ptr_tensor(self.input_block_tables)
 
         self.slot_mappings = torch.zeros(
             self.num_kv_cache_groups,
@@ -78,12 +66,33 @@ class BlockTables:
             device=self.device,
         )
 
+        self.init_block_table_layout_tensors()
+
     def _make_ptr_tensor(self, x: Iterable[torch.Tensor]) -> torch.Tensor:
         # NOTE(woosuk): Use uint64 instead of int64 to cover all possible addresses.
         return torch.tensor(
             [t.data_ptr() for t in x], dtype=torch.uint64, device=self.device
         )
 
+    def init_block_table_layout_tensors(self) -> None:
+        # Called at init and after a CuMem kv_cache wake-up. The ptr tensors
+        # cache raw data_ptr() values that go stale once the underlying tensors
+        # are reallocated on wake; block_sizes_tensor needs re-populating
+        # because its storage lives under the kv_cache pool tag and comes back
+        # with undefined contents.
+        self.block_table_ptrs = self._make_ptr_tensor(
+            [b.gpu for b in self.block_tables]
+        )
+        self.block_table_strides = torch.tensor(
+            [b.gpu.stride(0) for b in self.block_tables],
+            dtype=torch.int64,
+            device=self.device,
+        )
+        self.block_sizes_tensor = torch.tensor(
+            self.block_sizes, dtype=torch.int32, device=self.device
+        )
+        self.input_block_table_ptrs = self._make_ptr_tensor(self.input_block_tables)
+
     def append_block_ids(
         self,
         req_index: int,
diff --git a/vllm/v1/worker/gpu/model_runner.py b/vllm/v1/worker/gpu/model_runner.py
index a3eb1589a3f..dfe50cb135d 100644
--- a/vllm/v1/worker/gpu/model_runner.py
+++ b/vllm/v1/worker/gpu/model_runner.py
@@ -558,6 +558,9 @@ class GPUModelRunner(LoRAModelRunnerMixin):
         del hidden_states, sample_hidden_states
         gc.collect()
 
+    def post_kv_cache_wake_up(self) -> None:
+        self.block_tables.init_block_table_layout_tensors()
+
     def reset_mm_cache(self) -> None:
         if self.encoder_cache is not None:
             self.encoder_cache.reset_mm_cache()
diff --git a/vllm/v1/worker/gpu_model_runner.py b/vllm/v1/worker/gpu_model_runner.py
index e2af34eecb9..53197a5c81a 100644
--- a/vllm/v1/worker/gpu_model_runner.py
+++ b/vllm/v1/worker/gpu_model_runner.py
@@ -884,6 +884,9 @@ class GPUModelRunner(
         self.encoder_cache.clear()
         self.late_interaction_runner.clear()
 
+    def post_kv_cache_wake_up(self) -> None:
+        self.init_fp8_kv_scales()
+
     @torch.inference_mode()
     def init_fp8_kv_scales(self) -> None:
         """
diff --git a/vllm/v1/worker/gpu_worker.py b/vllm/v1/worker/gpu_worker.py
index 19d0a68142e..d955f401d87 100644
--- a/vllm/v1/worker/gpu_worker.py
+++ b/vllm/v1/worker/gpu_worker.py
@@ -46,7 +46,7 @@ from vllm.tasks import SupportedTask
 from vllm.tracing import instrument
 from vllm.utils.mem_constants import GiB_bytes
 from vllm.utils.mem_utils import MemorySnapshot, format_gib, memory_profiling
-from vllm.utils.torch_utils import is_quantized_kv_cache, set_random_seed
+from vllm.utils.torch_utils import set_random_seed
 from vllm.v1.core.sched.output import GrammarOutput, SchedulerOutput
 from vllm.v1.kv_cache_interface import KVCacheConfig, KVCacheSpec
 from vllm.v1.outputs import (
@@ -192,15 +192,8 @@ class Worker(WorkerBase):
                     buffer.data.copy_(self._sleep_saved_buffers[name].data)
             self._sleep_saved_buffers = {}
 
-        # If the KV cache has just been woken up,
-        # the internal state of cache_engine must be reset,
-        # especially the FP8 scaling factor.
-        if (
-            (tags is None or "kv_cache" in tags)
-            and is_quantized_kv_cache(self.cache_config.cache_dtype)
-            and hasattr(self.model_runner, "init_fp8_kv_scales")
-        ):
-            self.model_runner.init_fp8_kv_scales()
+        if tags is None or "kv_cache" in tags:
+            self.model_runner.post_kv_cache_wake_up()
 
     def _maybe_get_memory_pool_context(self, tag: str) -> AbstractContextManager:
         if not self.vllm_config.model_config.enable_sleep_mode: